You can if you want it to explode in the microwave. If you can set it to zap at 90 w -160 w for 30s and drop it in warm water, you can start t and quicken the defrosting process but the longer it is in there the more likely it is to explode. The problem with zapping is that there are trapped gasses in the food which expand as it heats. Be wary of zapping food as well, as it tends to denature some nutrients and minerals, and as pythons do not have the luxury of being able to eat a variety of fruits and vegies, getting the right nutrients is important.