what are they like during the day ?
imo STOP trying to handle them every night , i think that in some cases this can be the worst thing to do , and might just be your problem
i got a coastal that was a night mare when i got him (few years old when purchased ) i dont think his previous owner was the best of owners either so could of had a reason as to why he was like it , the moment that door opened he would instantly get up in the "S" position and start hissing and striking
i tried the handling regularly bit , just got me bit it did
then i tried a diffrent approach , i just let him do his thing and just be a snake with minimum interference/stress , it has worked absolute wonders , i still dont handle him regularly but when i get him out for a cage clean i can actually handle him now he still hisses and carries on sometimes but if his out and about and i open the door and let him come out his fine although this has taken about a year so it definitely takes patience
also look at your handling methods , i dont just go in and grab any of my snakes , i would hate it if someone did that to me and id probably give them a good whack for it myself , approach them slowly but with confidence and try not to be ruff with them
good luck , the above has worked for me and as i said maybe just let them simply be a snake and get used to you in their time through the glass where they feel safe , sooner or later their going to realise your no threat