I agree with Scleropages, I have both Smooth Knob tails and a baby thick tail and both have their moments when they carry on if I'm moving to a tub for cleaning. I wouldn't recommend them to be handled as if you would a Beardie (which I also have, he will be calm as anything if I was to take him out to give him some natural light or to clean etc). I keep the handling to a bare minimum and only when I need to move them out of their current tubs for cleaning (which isn't every day). They are very delicate and I don't want to stress them out by handling them.
Just adding, They don't have the toe pads like some other geckos so he wouldn't be sitting on his head for very long.