I think someone said you can use fleabombs, but you need to remove all animals for a while when doing that, I used surface spray away from the python, on the carpet and around the outside of the cage but not where he can touch it.
make sure your temps are right 32 and the basking spot and cool as your room temps the rest, you will see mites in the water if you have them, if it's eaten rats before you should be ok, it might not be hungry when its shedding, the eye will go clear a day or so before it will shed, and make sure his food is warm through before you feed it to him.
if he ate on the 13th he probably only missed 1 meal on the 17-18th as he is coming up to a shed, so don't handle him until he's shed and after his next feed
