Often when they have cloudy eyes they can be skittish or even agressive.
I believe it is because they feel vulnerable, not being able to see, and just not being their usual selves in general.
I know my Olive won't have a bar of me when her eyes are clouded but my Coastal Diamond and Mac are not so worried.
Even so, I like to give all of them their privacy when they are about to shed. I will look in and check on them but never handle unless I have to when they are in this state.
I've heard that handling them when in this state you can damage the skin underneath. I don't know if this is true, but I figure better safe than sorry and leave them alone till they have shed.